منابع مشابه
Investigating the effects of Thymol on animal model of Rheumatoid Arthritis
BBackground & Objectives: Nowadays, attention to natural products with therapeutic potential has been increased. This study was carried out to investigate the effect of Thymol on the animal model of Rheumatoid arthritis (RA). Materials & Methods: RA was induced by injection of complete Freund's adjuvant into the footpad of Wistar rats. Then, rats were allocated in 3 groups: treated with Thymol ...
متن کاملAnimal models of rheumatoid arthritis.
Animal models of arthritis are used to study pathogenesis of disease and to evaluate potential anti-arthritic drugs for clinical use. Therefore morphological similarities to human disease and capacity of the model to predict efficacy in humans are important criteria in model selection. Animal models of rheumatoid arthritis (RA) with a proven track record of predictability for efficacy in humans...
متن کاملTh17 in Animal Models of Rheumatoid Arthritis
IL-17-secreting helper CD4 T cells (Th17 cells) constitute a newly identified subset of helper CD4 T cells that play a key role in the development of rheumatoid arthritis (RA) in its animal models. Recently, several models of spontaneous RA, which elucidate the mechanism of RA onset, have been discovered. These animal models shed new light on the role of Th17 in the development of autoimmune ar...
متن کاملEarly arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis
INTRODUCTION Arthritis induces joint erosions and skeletal bone fragility. OBJECTIVES The main goal of this work was to analyze the early arthritis induced events at bone architecture and mechanical properties at tissue level. METHODS Eighty-eight Wistar rats were randomly housed in experimental groups, as follows: adjuvant induced arthritis (AIA) (N = 47) and a control healthy group (N = 4...
متن کاملImmunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis.
We described a prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65-kDa heat shock protein (DNA-hsp65) in experimental murine tuberculosis. However, high homology of the vaccine to the corresponding mammalian hsp60, together with the CpG motifs in the plasmidial vector, could trigger or exacerbate an autoimmune disease. In the present study, we evaluate the ...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2012
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.101.2839